Do you know what an Ionophore is?

May 10, 2023

Written by Heidi Wayment, M.S., Nutritionist at Draper IFA Feed.
Ionophores are considered a class of antibiotics without all the negative hype associated with antibiotics.
Ionophores – which you might know as Rumensin® (Monensin Sodium) or Bovatec® (Lasalosid Sodium) – are used in cattle production to shift ruminal fermentation patterns. They are not bactericidal (they do not kill the bacteria); they simply inhibit their functionality and ability to reproduce.
The name ionophore has been used to denote this group of compounds because of their ability to transport ions across biological membranes. The ion transport capability is the key to their anticoccidial and antibacterial activities. In ruminants, the antibacterial effects result in changed ruminal microflora and growth promotant effects.
History of Ionophores in Livestock Production
Before these ionophores were legally marketed for use in food-producing animals, companies had to demonstrate to regulatory agencies that each drug was safe and effective in the target animal species, safe for humans consuming edible products from treated animals, and safe for the environment.
The increase in antibiotic-resistant bacteria as a result of ionophore use is not well supported for several reasons:
  1. Ionophores never have been – nor are likely to be – used as antimicrobials in humans.
  2. Ionophores have a very different mode of action from therapeutic antibiotics.
  3. Ionophore resistance in bacteria seems to be an adaptation rather than a mutation or acquisition of foreign genes.
How Ionophores Work
In the rumen, the first chamber in cattle stomachs, microorganisms convert feed to volatile fatty acids (VFAs). These VFAs are absorbed from the rumen and supply the majority of energy cattle need. The three major VFAs produced in the rumen are acetate, propionate, and butyrate. Acetate is produced in the greatest quantity, followed by propionate, and finally butyrate.
Although they are the largest proportion of the ruminal VFAs, bacteria that make acetate from glucose are inefficient because every conversion of glucose to acetate represents an energy loss, usually as methane. Energy loss equals inefficiency. However, when microorganisms convert glucose to propionate, there is no net energy loss. Propionate production, therefore, represents a more energetically efficient pathway in the rumen.
Ionophores inhibit acetate-forming bacteria, which gives a competitive advantage to the propionate-producing bacteria. This equals a more energy-efficient pathway in the rumen.
Ionophores cost roughly 2 cents per head per day. One of the reasons for the large adaptation of this technology is the consistent return on investment. The net return on investment when ionophores are fed to cattle equals approximately $20 per head (Elanco Animal Health, 2015). Return on investment in ionophores is due to the 5-10% increase in feed efficiency noted in cattle-fed ionophores when compared to those that are not fed ionophores.
The Effects of Ionophores on Cattle
One research study conducted at Oklahoma State University showed cows maintaining the same body condition on 10% less hay when consuming an ionophore, compared to cows that did not receive the ionophore. The inclusion of ionophores in heifer diets has been shown to increase the number of heifers that have reached puberty by the start of the breeding season, decrease the age at puberty, and decrease the weight at puberty.
Ionophores can help reduce the impact of drought-induced forage losses by allowing the ruminal shift in VFAs to get the most energy out of the low-quality forage.
Should you be Using Ionophores?
In conclusion, ionophores are a non-medically relevant class of antibiotics. Thus, they are not regulated by the VFD (veterinary feed directive) and are considered safe and efficient. Ionophores shift ruminal fermentation to increase cattle feed efficiency, which improves profitability, as well as reduces methane production from cattle operations.

Your local Co-op can help answer any additional questions you have about ionophores. For more content like this, check out the latest issue of The Cooperator.

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